Next Generation Sequencing

Swift Biosciences is developing a suite of differentiated technologies to improve next generation sequencing (NGS) sample preparation. These technologies are based on proprietary protocols and reagents invented by Swift. Among the applications under development:

  • DNA library creation
  • Targeted selection
  • RNA-seq

 All of these applications share the features of being fast, easy and compatible with existing NGS instrumentation.

A Timeline of Product Introduction

Accel-NGS® DNA Library Kit for Ion Torrent™

Using this kit, NGS users can produce PCR-free libraries with as little as 5 ng of input DNA. Unlike other kits on the market, novel Swift technology utilized in the Accel-NGS DNA Library Kit for Ion Torrent does not require intact double-stranded DNA, making it compatible with damaged samples and single-stranded DNA for DNA sequencing.

Accel-NGS 1S Plus DNA Library Kit for Illumina®

Similar to technology in the Accel-NGS DNA Library Kit for Ion Torrent, the expansion for the Illumina platform does not require inputs of intact double-stranded DNA. Users can produce high quality DNA libraries from as little as 10 pg with PCR. This kit is ideal for single-stranded genomes, difficult-to-extract samples where harsher extraction methods are needed, heat-denatured pathogens, and ChIP-Seq.

Accel-NGS 2S Plus & PCR-Free DNA Library Kits for Illumina

Library prep incorporating novel, patent-pending technology that enables users to produce libraries from as little as 10 pg of input with PCR and PCR-free libraries from just 10 ng. The Accel-NGS 2S Plus and PCR-Free DNA Library Kits offer exceptional quality and evenness of coverage and are ideally suited for clinical samples such as FFPE, plasma, and cell-free DNA. These kits are also compatible with amplicons and the leading hybridization capture products for exome analysis.

Accel-NGS Methyl-Seq Library Kit for Illumina

Utilizing a highly efficient adapter attachment chemistry compatible with single-stranded, bisulfite-converted DNA, users maximize DNA recovery through post-bisulfite library preparation. This process eliminates up to 95% library loss found in workflows with bisulfite treatment after library construction. The Accel-NGS Methyl-Seq Library kit maximizes DNA recovery of bisulfite converted samples and constructs libraries that accurately represent sample base composition.

Accel-Amplicon Panels for Illumina

Amplicon technology based on unique molecular biology to provide powerful solutions for detecting and screening clinically relevant mutations.  Accel-Amplicon Panels are comprised of 10's to 100's of primer pairs in a single-tube format which are optimized for sequencing on Illumina platforms. Primer pairs in the panels are designed for compatibility with the short DNA fragments from both FFPE and circulating cell-free DNA samples. A fast and easy single-tube workflow produces the best-in-class performance for on-target percentage and coverage uniformity, enabling variant discovery and confirmation.

Accel-NGS products for RUO applications are available directly from Swift Biosciences. To learn more about the growing range of Accel-NGS DNA Library Kits, click here.